CKIɛ/discs overgrown Promotes Both Wnt-Fz/β-Catenin and Fz/PCP Signaling in Drosophila
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CKIɛ/discs overgrown Promotes Both Wnt-Fz/β-Catenin and Fz/PCP Signaling in Drosophila
The related Wnt-Frizzled(Fz)/b-catenin and Fz/planar cell polarity (PCP) pathways are essential for the regulation of numerous developmental processes and are deregulated in many human diseases. Both pathways require members of the Dishevelled (Dsh or Dvl) family of cytoplasmic factors for signal transduction downstream of the Fz receptors. Dsh family members have been studied extensively, but ...
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will break the barrier, making the TJ a frequent contributor to a vast range of pathologies of blood vessels and epithelial organs. Since most of these insults have pleotropic cellular effects, it is difficult to envision therapies that could target specific TJ components or functions. In contrast, some assaults on the barrier are quite specific. For example, house dust mites excrete a fecal pr...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.06.030